Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India

J Pediatr Endocrinol Metab. 2016 Dec 1;29(12):1373-1377. doi: 10.1515/jpem-2016-0191.


Background: Vitamin D deficiency is a widely recognized public health problem. Efficacy of a recently developed micellized form of vitamin D3 has not been studied. Hence, we undertook this study to compare its efficacy with the conventionally used fat-soluble vitamin D3.

Methods: In this open-labeled nonrandomized pilot study, we recruited 180 healthy children, aged 13-14 years in two groups and supplemented Group A (60 children) with 60,000 IU of fat-soluble vitamin D3/month with milk and Group B (120 children) with 60,000 IU/month of water miscible vitamin D3 under supervision for 6 months. Serum 25(OD)D, parathyroid hormone (PTH), calcium, phosphate, and alkaline phosphatase (ALP) levels were evaluated before and after supplementation in 156 children (54 in Group A and 102 in Group B) who completed the study.

Results: We observed a significantly greater increase in the serum 25(OH)D levels in group B as compared to group A (31.8±9.1 ng/mL vs. 23.7±10.4 ng/mL; p<0.001). All children in group B achieved adequate levels of serum 25(OH)D (>20 ng/mL) as against 83.3% children in group A. Serum PTH and ALP levels declined considerably in both the groups following supplementation.

Conclusions: Vitamin D supplementation significantly increased the serum 25(OH)D levels in both groups. Miscible form of vitamin D3 appears to be better in achieving higher levels of serum 25(OH)D than that observed with a similar dose of fat-soluble vitamin D3. Further studies with different dose regimens are required to establish its efficacy over the conventionally used fat-soluble vitamin D3.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Child
  • Cholecalciferol / administration & dosage*
  • Dietary Supplements*
  • Fatty Acids / chemistry*
  • Female
  • Follow-Up Studies
  • Humans
  • India
  • Male
  • Micelles
  • Pilot Projects
  • Prognosis
  • Vitamin D / administration & dosage*
  • Vitamin D Deficiency / prevention & control*


  • Fatty Acids
  • Micelles
  • Vitamin D
  • Cholecalciferol