HIV Broadly Neutralizing Antibodies: Taking Good Care Of The 98

Immunity. 2016 Nov 15;45(5):958-960. doi: 10.1016/j.immuni.2016.10.033.


In this issue of Immunity, Huang et al. (2016) describe an exceptionally broad and potent neutralizing antibody to HIV. This antibody, N6, is capable of neutralizing up to 98% of global isolates with a potent median IC50 of 0.04 μg/mL, making it the current "best-in-class" for bNAbs targeting the CD4 binding site.

Publication types

  • Comment

MeSH terms

  • Antibodies, Neutralizing / immunology*
  • HIV Antibodies / chemistry*
  • HIV Infections / immunology
  • HIV-1 / immunology
  • Humans


  • Antibodies, Neutralizing
  • HIV Antibodies