Objective: To assess the association of the traditional risk factors of coronary artery disease(CAD) and degree of coronary artery plaque. Methods: A total of 3 752 patients who had a suspicion of CAD from September 2011 to November 2012 at the First Hospital of China Medical University underwent the coronary artery computed tomography. The univariable and multivariable Logistic regression were employ to assess the association the traditional risk factors of CAD and degree of coronary artery plaque. Results: Age, diabetes, hypertension and smoking were the independent risk factor for significant stenosis, multivessel lesions and high coronary artery calcium score(all P <0.05), male was an independent risk factor for significant stenosis(P=0.039), however HDL-C was the independent protect factor(all P<0.05). Conclusion: Age, diabetes, hypertension and smoking are the independent risk factor for degree of coronary artery plaque, HDL-C is the independent protect factor.Male is only an independent risk factor for significant stenosis.