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Review
. 2016;6(3):169-181.
doi: 10.15171/bi.2016.23. Epub 2016 Sep 30.

Radiolabeled Theranostics: Magnetic and Gold Nanoparticles

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Free PMC article
Review

Radiolabeled Theranostics: Magnetic and Gold Nanoparticles

Saeideh Same et al. Bioimpacts. .
Free PMC article

Abstract

Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems. Functionalized magnetic and gold NPs (MNPs and GNPs, respectively) have produced the potential of nanoparticles as sensitive multifunctional probes for molecular imaging, photothermal therapy and drug delivery and targeting. Methods: In this study, we review the most recent works on the improvement of various techniques for development of radiolabeled magnetic and gold nanoprobes, and discuss the methods for targeted imaging and therapies. Results: The receptor-specific radiopharmaceuticals have been developed to localized radiotherapy in disease sites. Application of advanced multimodal imaging methods and related modality imaging agents labeled with various radioisotopes (e.g., 125I, 111In, 64Cu, 68Ga, 99mTc) and MNPs/GNPs have significant effects on treatment and prognosis of cancer therapy. In addition, the surface modification with biocompatible polymer such as polyethylene glycol (PEG) have resulted in development of stealth NPs that can evade the opsonization and immune clearance. These long-circulating agents can be decorated with homing agents as well as radioisotopes for targeted imaging and therapy purposes. Conclusion: The modified MNPs or GNPs have wide applications in concurrent diagnosis and therapy of various malignancies. Once armed with radioisotopes, these nanosystems (NSs) can be exploited for combined multimodality imaging with photothermal/photodynamic therapy while delivering the loaded drugs or genes to the targeted cells/tissues. These NSs will be a game changer in combating various cancers.

Keywords: Nuclear imaging; PET/SPECT; Radiolabeled nanoparticles; Theranostics.

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References

    1. Lin J, Li Y, Li Y, Wu H, Yu F, Zhou S. et al. Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging. ACS Appl Mater Interfaces. 2015;7:11908–20. doi: 10.1021/acsami.5b01685. - DOI - PubMed
    1. Heidari Majd M, Asgari D, Barar J, Valizadeh H, Kafil V, Abadpour A. et al. Tamoxifen loaded folic acid armed PEGylated magnetic nanoparticles for targeted imaging and therapy of cancer. Colloids Surf B Biointerfaces. 2013;106:117–25. doi: 10.1016/j.colsurfb.2013.01.051. - DOI - PubMed
    1. Omidi Y, Barar J. Induction of human alveolar epithelial cell growth factor receptors by dendrimeric nanostructures. Int J Toxicol. 2009;28:113–22. doi: 10.1177/1091581809335177. - DOI - PubMed
    1. Hartono SB, Gu W, Kleitz F, Liu J, He L, Middelberg AP. et al. Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery. ACS Nano. 2012;6:2104–17. doi: 10.1021/nn2039643. - DOI - PubMed
    1. Ezzati Nazhad Dolatabadi J, Omidi Y. Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems. TrAC Trends in Analytical Chemistry. 2016;77:100–8. doi: 10.1016/j.trac.2015.12.016. - DOI

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