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. 2017 Jan;12(2):147-164.
doi: 10.2217/nnm-2016-0335. Epub 2016 Nov 17.

Inhibition of Breast Cancer Metastasis by Paclitaxel-Loaded pH Responsive Poly(β-Amino Ester) Copolymer Micelles

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Inhibition of Breast Cancer Metastasis by Paclitaxel-Loaded pH Responsive Poly(β-Amino Ester) Copolymer Micelles

Yanjun Chen et al. Nanomedicine (Lond). .

Abstract

Aim: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(β-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis.

Materials & methods: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice.

Results: PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis.

Conclusion: The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis.

Keywords: anticancer; invasion; metastasis; migration; paclitaxel; poly(β-amino ester).

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