Rotating waves during human sleep spindles organize global patterns of activity that repeat precisely through the night

Elife. 2016 Nov 15;5:e17267. doi: 10.7554/eLife.17267.

Abstract

During sleep, the thalamus generates a characteristic pattern of transient, 11-15 Hz sleep spindle oscillations, which synchronize the cortex through large-scale thalamocortical loops. Spindles have been increasingly demonstrated to be critical for sleep-dependent consolidation of memory, but the specific neural mechanism for this process remains unclear. We show here that cortical spindles are spatiotemporally organized into circular wave-like patterns, organizing neuronal activity over tens of milliseconds, within the timescale for storing memories in large-scale networks across the cortex via spike-time dependent plasticity. These circular patterns repeat over hours of sleep with millisecond temporal precision, allowing reinforcement of the activity patterns through hundreds of reverberations. These results provide a novel mechanistic account for how global sleep oscillations and synaptic plasticity could strengthen networks distributed across the cortex to store coherent and integrated memories.

Keywords: electrocortiogram; human; neuroscience; sleep oscillations; sleep spindles; spatiotemporal dynamics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Brain Waves*
  • Cerebral Cortex / physiology*
  • Electrocorticography
  • Humans
  • Memory*
  • Sleep*
  • Spatio-Temporal Analysis
  • Thalamus / physiology*