Role of Low-Level Laser Therapy as an Adjunct to Initial Periodontal Treatment in Type 2 Diabetic Patients: A Split-Mouth, Randomized, Controlled Clinical Trial

Photomed Laser Surg. 2017 Feb;35(2):111-115. doi: 10.1089/pho.2016.4117. Epub 2016 Nov 17.


Objective: In this split-mouth clinical trial, we evaluated the clinical benefits of low-level laser therapy (LLLT) as an adjunct to nonsurgical periodontal treatment in patients with type 2 diabetes mellitus (DM).

Background data: The impaired wound healing seen in diabetic patients may affect the results of periodontal treatment and may require an additional approach.

Materials and methods: In total, 22 chronic periodontitis patients with type 2 DM were included. Applying a split-mouth design, two quadrants were treated with only scaling and root planing (SRP) as the control and those in the other two were treated with SRP + LLLT as the test sites in each patient. An 808 nm GaAlAs diode laser was performed in the test sites at the energy density of 4.46 J/cm2 on days 1, 2, and 7 after SRP. Plaque index (PI), probing depth (PD), bleeding on probing (BOP), and clinical attachment level were measured at baseline and again at 1 and 3 months after treatment. Deep periodontal pockets (PD ≥4 mm) were evaluated separately.

Results: Test sites showed significant improvement in PI and BOP in deep pockets at the 1-month follow-up period (p < 0.001 and <0.001, respectively), whereas no difference was found between the control and the test sites in other periodontal parameters.

Conclusions: LLLT during periodontal treatment offered minimal short-term additional benefit in deep pocket healing in patients with type 2 DM.

Keywords: diabetes mellitus type 2; laser therapy; low level; periodontology.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chronic Periodontitis / complications*
  • Chronic Periodontitis / diagnosis
  • Chronic Periodontitis / radiotherapy*
  • Chronic Periodontitis / surgery
  • Combined Modality Therapy
  • Debridement / methods
  • Dental Plaque Index
  • Dental Scaling / methods
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / diagnosis
  • Female
  • Humans
  • Low-Level Light Therapy / methods*
  • Male
  • Middle Aged
  • Patient Safety*
  • Prospective Studies
  • Reference Values
  • Risk Assessment
  • Statistics, Nonparametric
  • Treatment Outcome