Adaptor Proteins of Type VI Secretion System Effectors

Daniel Unterweger; Benjamin Kostiuk; Stefan Pukatzki

doi:10.1016/j.tim.2016.10.003

Adaptor Proteins of Type VI Secretion System Effectors

Trends Microbiol. 2017 Jan;25(1):8-10. doi: 10.1016/j.tim.2016.10.003. Epub 2016 Nov 14.

Authors

Daniel Unterweger¹, Benjamin Kostiuk², Stefan Pukatzki³

Affiliations

¹ Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada; Current address: Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.
² Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada.
³ Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada; Department of Immunology & Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: stefan.pukatzki@ucdenver.edu.

PMID: 27856117
DOI: 10.1016/j.tim.2016.10.003

Abstract

Bacteria use the type VI secretion system (T6SS) to kill neighboring cells. One key feature of the T6SS is the secretion of diverse effectors. Here, we discuss six publications that describe three superfamilies of T6SS proteins, each dedicated to mediate the secretion of cognate effectors.

Keywords: accessory protein; adaptor protein; chaperone; diversity.; effector translocation; type VI secretion system.

MeSH terms

Agrobacterium tumefaciens / pathogenicity*
Bacterial Proteins / metabolism
Pseudomonas aeruginosa / pathogenicity*
Serratia marcescens / pathogenicity*
Type VI Secretion Systems / metabolism*
Vibrio cholerae / pathogenicity*

Substances

Bacterial Proteins
Type VI Secretion Systems