Infection and inflammation in schizophrenia and bipolar disorder

Teppei Tanaka; Taro Matsuda; Lindsay N Hayes; Shuojia Yang; Katrina Rodriguez; Emily G Severance; Robert H Yolken; Akira Sawa; William W Eaton

doi:10.1016/j.neures.2016.11.002

Infection and inflammation in schizophrenia and bipolar disorder

Neurosci Res. 2017 Feb:115:59-63. doi: 10.1016/j.neures.2016.11.002. Epub 2016 Nov 14.

Authors

Teppei Tanaka¹, Taro Matsuda², Lindsay N Hayes¹, Shuojia Yang³, Katrina Rodriguez², Emily G Severance³, Robert H Yolken⁴, Akira Sawa⁵, William W Eaton⁶

Affiliations

¹ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
² Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA.
³ Stanley Laboratory of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁴ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Stanley Laboratory of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
⁵ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA. Electronic address: asawa1@jhmi.edu.
⁶ Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21287, USA. Electronic address: weaton1@jhu.edu.

PMID: 27856235
DOI: 10.1016/j.neures.2016.11.002

Abstract

The present study investigated the relationship between exposure to infectious agents and inflammation markers in individuals with schizophrenia (SZ), bipolar disorder (BP), and controls without a psychiatric disorder. We measured plasma levels of antibodies and innate immune markers and correlated them with clinical symptoms and cognitive function. In both SZ and BP, we found an increase in soluble CD14, and in BP an increase in C-reactive protein, IgM class antibodies against cytomegalovirus (CMV), and IgG class antibodies against herpes simplex virus 2. Furthermore in BP, we observed a negative relationship between IgG antibodies against CMV and scores for cognitive function.

Keywords: Antibody level; Bipolar disorder; Inflammation; Neurocognition; Schizophrenia.

MeSH terms

Adult
Antibodies, Protozoan / blood*
Antibodies, Viral / blood*
Biomarkers / blood
Bipolar Disorder / blood
Bipolar Disorder / complications
Bipolar Disorder / parasitology*
Bipolar Disorder / virology*
C-Reactive Protein / analysis*
Case-Control Studies
Cytomegalovirus / immunology
Female
Herpesvirus 1, Human / immunology
Herpesvirus 2, Human / immunology
Humans
Infections / blood
Infections / complications
Infections / parasitology
Infections / virology
Inflammation / blood
Lipopolysaccharide Receptors / blood*
Male
Middle Aged
Schizophrenia / blood
Schizophrenia / complications
Schizophrenia / parasitology*
Schizophrenia / virology*
Serum Amyloid P-Component / analysis*
Toxoplasma / immunology

Substances

Antibodies, Protozoan
Antibodies, Viral
Biomarkers
Lipopolysaccharide Receptors
Serum Amyloid P-Component
PTX3 protein
C-Reactive Protein