Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides

Lertyot Treeratanapiboon; Apilak Worachartcheewan; Thummaruk Suksrichavalit; Rachada Kiatfuengfoo; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul

Bioactive 4-hydroxycinnamide and bioactivities of Polyalthia cerasoides

EXCLI J. 2011 Mar 8:10:16-22. eCollection 2011.

Authors

Lertyot Treeratanapiboon¹, Apilak Worachartcheewan², Thummaruk Suksrichavalit³, Rachada Kiatfuengfoo⁴, Supaluk Prachayasittikul⁵, Somsak Ruchirawat⁶, Virapong Prachayasittikul⁷

Affiliations

¹ Center for Innovation Development and Technology Transfer, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Parasitology and Community Health, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
² Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
³ Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
⁴ Department of Parasitology and Community Health, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
⁵ Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.
⁶ Chulabhorn Research Institute and Chulabhorn Graduate Institute, Bangkok 10210, Thailand.
⁷ Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

PMID: 27857661
PMCID: PMC5109010

Abstract

Constituents from Polyalthia cerasoides, stem bark methanol extract, were previously documented. This study reports the first isolation of bioactive N-(4-hydroxy-β-phenethyl)-4-hydroxycinnamide (1) from ethyl acetate extract of the plant species including stigmasterol and a mixture of triterpenes from hexane and dichloromethane extracts. Trace essential elements were found in the hexane extract in ppm level. The plant extracts were evaluated for their antimicrobial and antioxidative activities. The dichloromethane extract displayed the highest activity against Corynebacterium diphtheriae NCTC 10356 with MIC of 32 µg/mL, as well as, the highest SOD activity with an IC₅₀ of 4.51 µg/mL.

Keywords: 4-hydroxycinnamide; Polyalthia cerasoides; antimicrobials; antioxidants; trace elements.