N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc

EMBO J. 1989 Mar;8(3):749-55.

Abstract

To assess the impact of constitutive N-myc expression on lymphocytes, we generated lines of transgenic mice bearing the murine N-myc oncogene coupled to the immunoglobulin heavy chain enhancer (E mu). As in mice carrying an analogous c-myc construct, E mu-N-myc mice exhibit a limited overgrowth of cycling pre-B cells and eventually succumb to clonal B lymphoid tumours. The endogenous N-myc and c-myc alleles are silent in both E mu-N-myc and E mu-myc lymphomas, suggesting that these genes are subject to auto- and cross-regulation. The regulatory interaction and the similar biological effects of N-myc and c-myc imply that the two genes perform interchangeable functions in the promotion of cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • Cell Cycle
  • Cell Division
  • Enhancer Elements, Genetic
  • Gene Expression Regulation
  • Genes, Immunoglobulin
  • Lymphoma / genetics*
  • Lymphoma / pathology
  • Mice
  • Mice, Transgenic
  • Precancerous Conditions / genetics
  • Proto-Oncogenes*