Interleukin-1 and glucose homeostasis: an example of the biological relevance of immune-neuroendocrine interactions

Horm Res. 1989;31(1-2):94-9. doi: 10.1159/000181095.


Interleukin-1 (IL-1), a cytokine mainly produced by monocytes-macrophages, plays a crucial role in immunological and inflammatory processes. We have recently demonstrated that IL-1 can also affect neuroendocrine mechanisms. In this paper, we refer to the capacity of IL-1 to affect glucose homeostasis. In normal mice, low doses of IL-1 induce a long-lasting hypoglycemia which is not dependent on possible insulin-secretagogue actions of this cytokine. The hypoglycemic effect of IL-1 is also observed in insulin-resistant diabetic mice. Furthermore, IL-1 seems to adjust the 'set point' for glucose regulation to a lower level. The effects of IL-1 on glucose homeostasis constitute a clear example of the biological relevance of immune-neuroendocrine interactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 1 / metabolism*
  • Glucose / metabolism*
  • Homeostasis / drug effects*
  • Interleukin-1 / pharmacology*
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL


  • Interleukin-1
  • Glucose