Adenosine Producing Mesenchymal Stem Cells

Stem Cells. 2017 Jun;35(6):1647-1648. doi: 10.1002/stem.2532. Epub 2016 Nov 22.


Recent findings support the importance of the adenosine pathway in human immunology. Tissue specific differences exist with respect to the capacity of mesenchymal stem cells (MSC) to produce immune regulatory ATP metabolites. While some MSC may produce adenosine in a cell-autonomous fashion, other types of MSC require the cooperative activity of T-cells. Stem Cells 2017;35:1647-1648.

Keywords: Adenosine; Head and neck cancer; Mesenchymal stem cells; Microenvironment; Treg; Tumor.

Publication types

  • Letter

MeSH terms

  • Adenosine / biosynthesis*
  • Antigens, CD / metabolism
  • Humans
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / metabolism*
  • Tumor Microenvironment


  • Antigens, CD
  • Adenosine