Nail involvement can predict enthesopathy in patients with psoriasis

J Dtsch Dermatol Ges. 2016 Nov;14(11):1102-1107. doi: 10.1111/ddg.12989. Epub 2016 Nov 10.

Abstract

Background: Although subclinical enthesopathy is a well-established diagnostic criterion for psoriatic arthritis (PsA), it is frequently overlooked, as many patients are asymptomatic. The possibility of finding a clinical clue predicting enthesopathy would help clinicians establish an early diagnosis of PsA.

Material and methods: A prospective single-center study of a total of 90 patients with psoriasis was conducted to assess the presence of entheseal abnormalities as detected by ultrasound, and to determine any correlation with nail involvement.

Results: Entheseal abnormalities were found in 23 patients (25.5 %), 19 (82.6 %) of whom showed nail involvement, whereas four (17.4 %) individuals did not. Enthesopathy was present in 31.1 % (19/61) of patients with onychopathy compared to 13.8 % (4/29) of those without nail involvement (p = 0.07). There was a significant correlation between target NAPSI score and evidence of enthesopathy. In addition, the number of nails affected also showed a significant correlation with the presence of enthesopathy (p = 0.035).

Conclusions: Clinical evidence of onychopathy may be the clue to an early diagnosis of enthesopathy in psoriasis patients.

MeSH terms

  • Age Distribution
  • Comorbidity
  • Early Diagnosis
  • Enthesopathy / diagnostic imaging*
  • Enthesopathy / epidemiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nail Diseases / diagnosis*
  • Nail Diseases / epidemiology*
  • Prevalence
  • Prognosis
  • Psoriasis / diagnosis*
  • Psoriasis / epidemiology*
  • Reproducibility of Results
  • Risk Assessment / methods
  • Risk Factors
  • Sensitivity and Specificity
  • Sex Distribution
  • Spain / epidemiology