Coordination-Induced Assembly of Intelligent Polysaccharide-Based Phototherapeutic Nanoparticles for Cancer Treatment

Adv Healthc Mater. 2016 Dec;5(24):3099-3104. doi: 10.1002/adhm.201600877. Epub 2016 Nov 18.

Abstract

Smart polysaccharide-based anticancer phototherapeutic nanoparticles are prepared via a coordination-induced assembly process. Upon irradiated with a near infrared laser, the nanoparticles are not only able to simultaneously generate reactive oxygen species and hyperthermia that ablate tumors, but also possess tumor microenvironment-responsive off/on near infrared fluorescence and enhancement in photothermal effect, making them promising theranostic platform of cancer.

Keywords: hyaluronic acid; multimodal imaging; photodynamic therapy; photosensitizers; photothermal therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry*
  • Cell Line, Tumor
  • Fever / drug therapy
  • Fluorescence
  • Humans
  • Infrared Rays
  • MCF-7 Cells
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry*
  • Neoplasms / drug therapy*
  • Phototherapy / methods
  • Polysaccharides / administration & dosage*
  • Polysaccharides / chemistry*
  • Reactive Oxygen Species / chemistry
  • Theranostic Nanomedicine / methods
  • Tumor Microenvironment / drug effects

Substances

  • Antineoplastic Agents
  • Polysaccharides
  • Reactive Oxygen Species