Antigen presentation by Toxoplasma gondii-infected cells to CD4+ proliferative T cells and CD8+ cytotoxic cells

J Parasitol. 1989 Jun;75(3):411-6.


Cytotoxic cells specific for Toxoplasma gondii-infected cells were detected in the peripheral blood leukocytes from a patient with acute toxoplasmosis. The cytotoxicity was mediated by CD5+, CD4-, CD8+ cells. The cytotoxic T cells lysed Toxoplasma-infected target cells with HLA class I restriction. Two types of T cell clones were established from peripheral blood leukocytes of a patient with chronic toxoplasmosis; one was a CD5+, CD4-, CD8+ cytotoxic cell specific for Toxoplasma-infected cells, and the other was a CD5+, CD4+, CD8- proliferative cell that responded to Toxoplasma antigen. Toxoplasma-infected cell-specific cytotoxic cloned T cells recognize the infected target cells in the context of the HLA class I molecules, and the CD8 molecule was involved in the cytotoxicity. Toxoplasma antigen-specific proliferative cloned T cells were stimulated by Toxoplasma antigen-pulsed or Toxoplasma-infected cells in conjunction with HLA-DR molecule on the target cells. Thus, antigen presentation by Toxoplasma-infected cells for activation of both cytotoxic and proliferative T cells has been demonstrated.

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Antigens, Differentiation, T-Lymphocyte / immunology
  • Antigens, Protozoan / immunology*
  • Cytotoxicity, Immunologic
  • HLA-DR Antigens / immunology
  • Histocompatibility Antigens Class I / immunology
  • Humans
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Cytotoxic / immunology*
  • Toxoplasma / immunology*
  • Toxoplasmosis / immunology*


  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Protozoan
  • HLA-DR Antigens
  • Histocompatibility Antigens Class I