Analysis of adverse events following immunization in Minas Gerais, Brazil, 2011: a cross-sectional study

Epidemiol Serv Saude. 2016 Jan-Mar;25(1):45-54. doi: 10.5123/S1679-49742016000100005.
[Article in English, Portuguese]


Objective: to analyze the main adverse events occurring following immunization in Minas Gerais State, Brazil, in 2011.

Methods: this is a cross-sectional study using secondary data from the Brazilian Information System on Adverse Events Following Immunization.

Results: 1,449 adverse events were found; more than half occurred in children under one year of age (56.1%; OR=1.39; 95%CI: 1.08;1.78); the highest rates per 100,000 doses administered were found in the Southern Triangle (36.3), Northwest (25.7) and Southern (22.7) areas of the state; tetravalent vaccine had the highest reactogenicity (46.1%) and hypotonic-hyporesponsive episode was the most frequent event (15.9%); events were significantly associated with inactivated vaccines (OR=4.08; 95%CI: 3.51;4.75); most of the reported events were closed as 'undefined' (58.9%).

Conclusion: events were found in all regions of Minas Gerais state and were most frequent following administration of inactivated vaccines and among children under one year of age.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Adverse Drug Reaction Reporting Systems
  • Age Distribution
  • Brazil
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Dioxygenases
  • Female
  • Histone Demethylases
  • Humans
  • Immunization
  • Immunization Programs
  • Immunization, Secondary
  • Infant
  • Male
  • Middle Aged
  • Nuclear Proteins
  • Sex Distribution
  • Vaccination / adverse effects*
  • Vaccines / adverse effects*
  • Young Adult


  • Nuclear Proteins
  • Vaccines
  • Dioxygenases
  • Histone Demethylases
  • RIOX2 protein, human