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Clinical Trial
. 2017 Mar;65(3):496-503.
doi: 10.1111/jgs.14679. Epub 2016 Nov 16.

High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial

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Clinical Trial

High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial

Adit A Ginde et al. J Am Geriatr Soc. .
Free PMC article


Objectives: To determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents.

Design: Randomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014.

Setting: Colorado long-term care facilities.

Participants: Long-term care residents aged 60 and older (n = 107).

Intervention: The high-dose group received monthly supplement of vitamin D3 100,000 IU, the standard-dose group received a monthly placebo (for participants taking 400-1,000 IU/d as part of usual care) or a monthly supplement of 12,000 IU of vitamin D3 (for participants taking <400 IU/d as part of usual care).

Measurements: The primary outcome was incidence of ARI during the 12-month intervention. Secondary outcomes were falls and fractures, 25-hydroxyvitamin D levels, hypercalcemia, and kidney stones.

Results: Participants (55 high dose, 52 standard dose) were randomized and included in the final analysis. The high-dose group had 0.67 ARIs per person-year and the standard-dose group had 1.11 (incidence rate ratio (IRR) = 0.60, 95% confidence interval (CI) = 0.38-0.94, P = .02). Falls were more common in the high-dose group (1.47 per person-year vs 0.63 in standard-dose group; IRR = 2.33, 95% CI = 1.49-3.63, P < .001). Fractures were uncommon and similar in both groups (high dose 0.10 vs standard dose 0.19 per person-year; P = .31). Mean trough 25-hydroxyvitamin D levels during the trial were 32. ng/mL in the high-dose group and 25.1 ng/mL in the standard-dose group. There was no hypercalcemia or kidney stones in either group.

Conclusion: Monthly high-dose vitamin D3 supplementation reduced the incidence of ARI in older long-term care residents but was associated with a higher rate of falls without an increase in fractures.

Keywords: falls; immunosenescence; nursing home; respiratory infection; vitamin D.

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Figure 1
Figure 1
CONSORT diagram for flow of participants in trial
Figure 2
Figure 2. Change in 25-hydroxyvitamin D levels in two randomized groups
Treatment groups: high dose vitamin D (solid line), standard dose vitamin D (dotted line)
Figure 3
Figure 3. Subgroup analyses of acute respiratory infection and fall outcomes
(A) Acute Respiratory Infection (B) Falls Abbreviations: 25OHD, 25-hydroxyvitamin D; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtrate rate

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