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. 2017 Sep;31(5):e22095.
doi: 10.1002/jcla.22095. Epub 2016 Nov 15.

Establishment of Complete Blood Count Reference Intervals for Chinese Preschoolers

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Free PMC article

Establishment of Complete Blood Count Reference Intervals for Chinese Preschoolers

Guo-Cheng Wang et al. J Clin Lab Anal. .
Free PMC article

Abstract

Background: Reference intervals are critical for interpreting test results of a clinical laboratory. The aim of this study was to establish local reference intervals of complete blood count for healthy preschoolers in China.

Methods: Three thousand eight hundred and twenty-one blood specimens from children aged 4 months to 6 years were collected and analyzed. Complete blood counts were determined by Sysmex XT-4000i Automated Hematology Analyzer. The nonparametric 2.5th to 97.5th percentile reference ranges were calculated according to CLSI EP28-A3c guideline.

Results: Reference intervals for each blood cell parameter are determinded as follows: total WBC 4.86-12.1×109 /L for males and 4.73-12.3×109 /L for females; RBC 4.13-5.32×1012 /L for males and 4.08-5.24×1012 /L for females; HGB 109-145 g/L for males and 111-143 g/L for females; HCT 33.1-41.2% for males and 33.3-41.1% for females; MCH 23.5-29.7 pg for males and 24.6-30.0 pg for females; MCHC 320-365 g/L for males and 321-362 g/L for females; MCV 71.4-85.1 fL for males and 73.8-86.9 fL for females; RDW-SD 33.5-41.9 fL for males and 33.5-41.0 fL for females; RDW-CV 12.0-15.2% for males and 11.8-14.5% for females; PLT 181-475×109 /L for males and 179-456×109 /L for females; PCT 0.18-0.44% for males and 0.18-0.43% for females; MPV 8.20-11.6 fL for males and 8.20-11.5 fL for females; PDW 8.40-14.4 fL for males and 8.40-14.0 fL for females; P-LCR 12.0-36.6% for males and 11.8-35.6% for females.

Conclusions: We established local complete blood count reference intervals for apparent healthy preschoolers in China. It is necessary to establishing region-specific reference intervals of complete blood count for preschoolers.

Keywords: complete blood count; preschoolers; reference intervals.

Figures

Figure 1
Figure 1
Continuous reference intervals of WBC, RBC, HGB, and PLT. Continuous three concentrations of four mainly hematologic analytes WBC, RBC, HGB, and PLT are lined according to Age. Upper, median, and lower continuous curves denote the 97.5th, 50th, and 2.5th percentile, respectively
Figure 2
Figure 2
Reference intervals comparison of hematology analytes WBC, RBC, HGB, and PLT. The ordinate axises denote concentrations of four mainly hematology analytes and primary axises (left) show for WBC,RBC, subsidiary axises(right) show for HGB PLT. Xicheng is a urban district of beijing;Heilongjiang and Mongolia are two northern provinces in China. (A) comparison of 2.5th percentile reference intervals; (B) comparison of 97.5th percentile reference intervals

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