Skin lesion in a patient with acute myeloid leukemia

Transpl Infect Dis. 2017 Feb;19(1). doi: 10.1111/tid.12635. Epub 2016 Dec 28.

Abstract

We present the case of a 51-year-old man with acute myeloid leukemia who developed fevers with a skin lesion following the first cycle of induction chemotherapy. Skin biopsy showed evidence of invasive fungal infection. Cultures remained negative, but polymerase chain reaction on tissue detected Rhizopus oryzae complex. The patient was started on liposomal amphotericin B and underwent surgical debridement. He was switched to posaconazole, with plans for allogeneic hematopoetic stem cell transplant in the future.

Keywords: acute myeloid leukemia; mucormycosis; skin lesion.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use
  • Antibiotic Prophylaxis / adverse effects
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use*
  • Biopsy
  • Debridement
  • Dermatomycoses / complications
  • Dermatomycoses / drug therapy*
  • Dermatomycoses / microbiology
  • Dermatomycoses / pathology
  • Febrile Neutropenia / drug therapy*
  • Febrile Neutropenia / etiology
  • Febrile Neutropenia / microbiology
  • Forearm
  • Humans
  • Immunocompromised Host
  • Induction Chemotherapy / adverse effects
  • Induction Chemotherapy / methods
  • Invasive Fungal Infections / microbiology
  • Invasive Fungal Infections / pathology
  • Invasive Fungal Infections / therapy*
  • Leukemia, Myeloid, Acute / drug therapy*
  • Male
  • Middle Aged
  • Mucormycosis / complications
  • Mucormycosis / microbiology
  • Mucormycosis / pathology
  • Mucormycosis / therapy*
  • Polymerase Chain Reaction
  • RNA, Fungal / isolation & purification*
  • Rhizopus / isolation & purification*
  • Triazoles / administration & dosage
  • Triazoles / therapeutic use

Substances

  • Antifungal Agents
  • RNA, Fungal
  • Triazoles
  • liposomal amphotericin B
  • posaconazole
  • Amphotericin B