Using a Redox Modality to Connect Synthetic Biology to Electronics: Hydrogel-Based Chemo-Electro Signal Transduction for Molecular Communication

Yi Liu; Chen-Yu Tsao; Eunkyoung Kim; Tanya Tschirhart; Jessica L Terrell; William E Bentley; Gregory F Payne

doi:10.1002/adhm.201600908

Using a Redox Modality to Connect Synthetic Biology to Electronics: Hydrogel-Based Chemo-Electro Signal Transduction for Molecular Communication

Adv Healthc Mater. 2017 Jan;6(1). doi: 10.1002/adhm.201600908. Epub 2016 Nov 18.

Authors

Yi Liu¹, Chen-Yu Tsao², Eunkyoung Kim¹, Tanya Tschirhart², Jessica L Terrell², William E Bentley^{1

2}, Gregory F Payne^{1

2}

Affiliations

¹ Institute for Bioscience and Biotechnology Research, University of Maryland, College Park, MD, 20742, USA.
² Fischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.

PMID: 27863177
DOI: 10.1002/adhm.201600908

Abstract

A hydrogel-based dual film coating is electrofabricated for transducing bio-relevant chemical information into electronical output. The outer film has a synthetic biology construct that recognizes an external molecular signal and transduces this input into the expression of an enzyme that converts redox-inactive substrate into a redox-active intermediate, which is detected through an amplification mechanism of the inner redox-capacitor film.

Keywords: electrodeposition; hydrogels; molecular communication; redox; synthetic biology.

MeSH terms

Electronics*
Hydrogels / chemistry*
Membranes, Artificial*
Oxidation-Reduction
Synthetic Biology*

Substances

Hydrogels
Membranes, Artificial