Molecular Imaging and Precision Medicine: PET/Computed Tomography and Therapy Response Assessment in Oncology

PET Clin. 2017 Jan;12(1):105-118. doi: 10.1016/j.cpet.2016.08.002. Epub 2016 Oct 5.


A variety of methods have been developed to assess tumor response to therapy. Standardized qualitative criteria based on 18F-fluoro-deoxyglucose PET/computed tomography have been proposed to evaluate the treatment effectiveness in specific cancers and these allow more accurate therapy response assessment and survival prognostication. Multiple studies have addressed the utility of the volumetric PET biomarkers as prognostic indicators but there is no consensus about the preferred segmentation methodology for these metrics. Heterogeneous intratumoral uptake was proposed as a novel PET metric for therapy response assessment. PET imaging techniques will be used to study the biological behavior of cancers during therapy.

Keywords: Molecular imaging; Oncology; PET/computed tomography; Precision medicine; Therapy response.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Fluorodeoxyglucose F18
  • Humans
  • Molecular Imaging*
  • Molecular Targeted Therapy
  • Neoplasms / diagnostic imaging*
  • Neoplasms / therapy*
  • Outcome Assessment, Health Care
  • Positron Emission Tomography Computed Tomography*
  • Precision Medicine*
  • Predictive Value of Tests
  • Prognosis
  • Radiopharmaceuticals


  • Biomarkers, Tumor
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18