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. 2016 Dec;94(10):578-587.
doi: 10.1016/j.ciresp.2016.07.008. Epub 2016 Nov 15.

Surgical Treatment of Non-Functioning Pancreatic Neuroendocrine Tumours Based on Three Clinical Scenarios

[Article in English, Spanish]
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Surgical Treatment of Non-Functioning Pancreatic Neuroendocrine Tumours Based on Three Clinical Scenarios

[Article in English, Spanish]
Juli Busquets et al. Cir Esp. .

Abstract

Introduction: The treatment of patients with non-functioning pancreatic neuroendocrine tumours (NFPNET) is resection in locally pancreatic disease, or with resectable liver metastases. There is controversy about unresectable liver disease.

Methods: We analysed the perioperative data and survival outcome of 63 patients who underwent resection of NFPNET between 1993 and 2012. They were divided into 3 scenarios: A, pancreatic resection (44patients); B, pancreatic and liver resection in synchronous resectable liver metastases (12patients); and C, pancreatic resection in synchronous unresectable liver metastases (6patients). The prognostic factors for survival and recurrence were studied.

Results: Distal pancreatectomy (51%) and pancreaticoduodenectomy (38%) were more frequently performed. Associated surgery was required in 44% of patients, including synchronous liver resections in 9patients. Two patients received a liver transplant during follow-up. According to the WHO classification they were distributed into G1: 10 (16%), G2: 45 (71%), and G3: 8 (13%). The median hospital stay was 11days. Postoperative morbidity and mortality were 49% and 1.6%, respectively. At the closure of the study, 43 (68%) patients were still alive, with a mean actuarial survival of 9.6years. The WHO classification and tumour recurrence were risk factors of mortality in the multivariate analysis. The median actuarial survival by scenarios was 131months (A), 102months (B), and 75months (C) without statistically significant differences.

Conclusions: Surgical resection is the treatment for NFPNET without distant disease. Resectable liver metastases in well-differentiated tumours must be resected. The resection of the pancreatic tumour with unresectable synchronous liver metastasis must be considered in well-differentiated NFPNET. The WHO classification grade and recurrence are risk factors of long-term mortality.

Keywords: Duodenopancreatectomía cefálica; Liver metastases; Liver resection; Metástasis hepáticas; Non-functioning pancreatic neuroendocrine tumour; Pancreatic resection; Pancreaticoduodenectomy; Resección hepática; Resección pancreática; Tumor neuroendocrino pancreático no funcionante.

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