Endocrine Hypertension: A Practical Approach

Adv Exp Med Biol. 2017:956:215-237. doi: 10.1007/5584_2016_26.


Elevated blood pressure resulting from few endocrine disorders (endocrine hypertension) accounts for a high proportion of cases of secondary hypertension. Although some features may be suggestive, many cases of endocrine hypertension remain silent until worked up for the disease. A majority of cases result from primary aldosteronism. Other conditions that can cause endocrine hypertension are: congenital adrenal hyperplasia, Liddle syndrome, pheochromocytomas, Cushing's syndrome, acromegaly, thyroid diseases, primary hyperparathyroidism and iatrogenic hormone manipulation. Early identification and treatment of the cause of endocrine hypertension may help to reduce morbidity and mortality related to these disorders. This article gives a comprehensive and practical approach to the diagnosis and management of endocrine hypertension.

Keywords: Acromegaly; Congenital adrenal hyperplasia; Cushing’s syndrome; Endocrine hypertension; Liddle syndrome; Pheochromocytoma; Primary aldosteronism; Primary hyperparathyroidism; Thyroid disease.

Publication types

  • Review

MeSH terms

  • Blood Pressure*
  • Diagnostic Techniques, Endocrine
  • Endocrine System Diseases / complications*
  • Endocrine System Diseases / diagnosis
  • Endocrine System Diseases / physiopathology
  • Endocrine System Diseases / therapy
  • Humans
  • Hypertension / diagnosis
  • Hypertension / etiology*
  • Hypertension / physiopathology
  • Hypertension / therapy
  • Predictive Value of Tests
  • Risk Factors
  • Treatment Outcome