Constitutive production of interleukin 6/B cell stimulatory factor-2 from inflammatory synovium

Clin Immunol Immunopathol. 1989 Aug;52(2):238-47. doi: 10.1016/0090-1229(89)90175-x.


Interleukin 6 (IL-6) production from synovial tissues of various diseases was examined. Augmented IL-6 production was found in inflammatory synovium not only in RA but also in other kinds of synovitis, including psoriatic arthritis and Behçet's disease. Increased amounts of IL-6-mRNA were detected in rheumatoid synovium using a dot blot hydridization technique. Furthermore, there was a positive correlation between IL-6 production and accumulation of plasma cells in the synovium. These findings suggest that IL-6 plays an important role not only in immune response but also in active inflammation in various kinds of synovitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / metabolism
  • Female
  • Humans
  • Interleukin-1 / biosynthesis
  • Interleukin-6
  • Interleukins / biosynthesis*
  • Interleukins / genetics
  • Male
  • Middle Aged
  • RNA, Messenger / analysis
  • Synovial Membrane / metabolism*
  • Synovial Membrane / pathology
  • Synovitis / metabolism*


  • Interleukin-1
  • Interleukin-6
  • Interleukins
  • RNA, Messenger