Primary association of HLA-DQw8 with type I diabetes in DR4 patients

Diabetes. 1989 Jul;38(7):942-5. doi: 10.2337/diab.38.7.942.


DNA from 164 Caucasian type I (insulin-dependent) diabetic patients and 200 Caucasian nondiabetic control blood donors were analyzed by the polymerase chain reaction technique for HLA-DR4 and the associated Dw and DQB subtypes of DR4. The DQw8 subtype of HLA-DR4 was associated with type I diabetes in all DR4 subgroups (DR4/3 and DR4/non-3). Dw subtypes of DR4 other than DW10 did not confer additional association with type I diabetes. Thus, the DQ region appears to provide the primary major histocompatibility association with type I diabetes in most DR4 patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Base Sequence
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology
  • Gene Frequency
  • HLA-DQ Antigens / genetics*
  • HLA-DQ Antigens / immunology
  • HLA-DR Antigens / genetics*
  • HLA-DR Antigens / immunology
  • HLA-DR4 Antigen
  • Humans
  • Immunoblotting
  • Molecular Sequence Data
  • Oligonucleotide Probes


  • HLA-DQ Antigens
  • HLA-DQ8 antigen
  • HLA-DR Antigens
  • HLA-DR4 Antigen
  • Oligonucleotide Probes