Mapping the 3D genome: Aiming for consilience

Nat Rev Mol Cell Biol. 2016 Nov 21;17(12):741-742. doi: 10.1038/nrm.2016.151.


The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, which can reconcile the datasets.

MeSH terms

  • Chromosome Mapping
  • Chromosomes / ultrastructure*
  • Genetic Loci
  • Genome, Human
  • Humans
  • Nucleic Acid Conformation