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Randomized Controlled Trial
. 2017 May;24(5):517-523.
doi: 10.1097/GME.0000000000000779.

Comparative Effectiveness of Electro-Acupuncture Versus Gabapentin for Sleep Disturbances in Breast Cancer Survivors With Hot Flashes: A Randomized Trial

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Free PMC article
Randomized Controlled Trial

Comparative Effectiveness of Electro-Acupuncture Versus Gabapentin for Sleep Disturbances in Breast Cancer Survivors With Hot Flashes: A Randomized Trial

Sheila N Garland et al. Menopause. .
Free PMC article

Abstract

Objective: Sleep disturbance is a major consequence of hot flashes among breast cancer survivors. This study evaluated the effects of electro-acupuncture (EA) versus gabapentin (GP) for sleep disturbances among breast cancer survivors experiencing daily hot flashes.

Methods: We analyzed data from a randomized controlled trial involving 58 breast cancer survivors experiencing bothersome hot flashes at least two times per day. Participants were randomly assigned to receive 8 weeks of EA or daily GP (total dose of 900 mg/d). The primary outcome was change in the total Pittsburgh Sleep Quality Index (PSQI) score between groups at week 8. Secondary outcomes include specific PSQI domains.

Results: By the end of treatment at week 8, the mean reduction in PSQI total score was significantly greater in the EA group than the GP group (-2.6 vs -0.8, P = 0.044). The EA also had improved sleep latency (-0.5 vs 0.1, P = 0.041) and sleep efficiency (-0.6 vs 0.0, P = 0.05) compared with the GP group. By week 8, the EA group had improved sleep duration, less sleep disturbance, shorter sleep latency, decreased daytime dysfunction, improved sleep efficiency, and better sleep quality (P < 0.05 for all) compared with baseline, whereas the GP group improved in duration and sleep quality only (P < 0.05).

Conclusions: Among women experiencing hot flashes, the effects of EA are comparable with GP for improving sleep quality, specifically in the areas of sleep latency and efficiency. Larger randomized controlled trials with longer follow-ups are needed to confirm this preliminary finding.

Trial registration: ClinicalTrials.gov NCT01005108.

Conflict of interest statement

Disclosure: The other co-authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Impact of electro-acupuncture and gabapentin on total sleep disturbance

Comment in

  • To the Editor.
    Moran JM, Aliaga I, Pedrera-Zamorano JD, Fernández AS. Moran JM, et al. Menopause. 2017 Jun;24(6):713. doi: 10.1097/GME.0000000000000865. Menopause. 2017. PMID: 28244935 No abstract available.
  • To the Editor.
    Banzoli CV, Bezerra AG, Tufik S, Hachul H. Banzoli CV, et al. Menopause. 2017 Jun;24(6):714. doi: 10.1097/GME.0000000000000868. Menopause. 2017. PMID: 28266947 No abstract available.
  • In Reply.
    Garland SN, Mao J. Garland SN, et al. Menopause. 2017 Jun;24(6):713-714. doi: 10.1097/GME.0000000000000866. Menopause. 2017. PMID: 28291029 No abstract available.
  • In Reply.
    Garland SN, Mao JJ. Garland SN, et al. Menopause. 2017 Jun;24(6):714-715. doi: 10.1097/GME.0000000000000867. Menopause. 2017. PMID: 28538543 No abstract available.

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