IL-6 roles - Molecular pathway and clinical implication in pancreatic cancer - A systemic review

Immunol Lett. 2017 Jan:181:45-50. doi: 10.1016/j.imlet.2016.11.010. Epub 2016 Nov 19.

Abstract

Pancreatic cancer has attracted a great deal of attention owing to the poor outcome, increasing prevalence in the last years and delay diagnosis. Known as a complex disease, it involves genetic mutations, changes in tumour microenvironment and inflammatory component dominated by interleukin-6 and its activated pathways, like Janus Kinase-Signal Transducer and Activator of Translation3, Mitogen Activated Protein Kinase and Androgen receptor. The pro-inflammatory cytokine, plays a central role in oncogenesis, cancer progression, invasiveness, microenvironment changes, treatment resistance, prognosis and associated co morbidities like cachexia and depression. Fulfilling these roles IL-6 requires special attention to understand its complexity in PC development.

Keywords: Interleukin-6; Oncogenesis; Pancreatic cancer; Prognosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Biomarkers, Tumor
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Interleukin-6* / genetics
  • Interleukin-6* / metabolism
  • Pancreatic Neoplasms* / drug therapy
  • Pancreatic Neoplasms* / metabolism
  • Pancreatic Neoplasms* / mortality
  • Pancreatic Neoplasms* / pathology
  • Prognosis
  • Signal Transduction*
  • Transcription Factors / metabolism
  • Tumor Microenvironment / genetics

Substances

  • Biomarkers, Tumor
  • Interleukin-6
  • Transcription Factors