A view of human haematopoietic development from the Petri dish

Nat Rev Mol Cell Biol. 2017 Jan;18(1):56-67. doi: 10.1038/nrm.2016.127. Epub 2016 Nov 23.

Abstract

Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Culture Techniques
  • Cell Differentiation
  • Hematopoiesis / physiology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology
  • Mice
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / physiology