A view of human haematopoietic development from the Petri dish

doi:10.1038/nrm.2016.127

Review

. 2017 Jan;18(1):56-67.

doi: 10.1038/nrm.2016.127. Epub 2016 Nov 23.

A view of human haematopoietic development from the Petri dish

Andrea Ditadi¹, Christopher M Sturgeon², Gordon Keller^{1

3}

Affiliations

¹ McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada.
² Department of Internal Medicine, Division of Hematology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
³ Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

PMID: 27876786
DOI: 10.1038/nrm.2016.127

Review

A view of human haematopoietic development from the Petri dish

Andrea Ditadi et al. Nat Rev Mol Cell Biol. 2017 Jan.

. 2017 Jan;18(1):56-67.

doi: 10.1038/nrm.2016.127. Epub 2016 Nov 23.

Authors

Andrea Ditadi¹, Christopher M Sturgeon², Gordon Keller^{1

3}

Affiliations

¹ McEwen Centre for Regenerative Medicine and Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 1L7, Canada.
² Department of Internal Medicine, Division of Hematology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
³ Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

PMID: 27876786
DOI: 10.1038/nrm.2016.127

Abstract

Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.

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References

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[1] Nat Biotechnol. 2014 Jun;32(6):554-61 - PubMed

[2] Nat Biotechnol. 2014 Jun;32(6):554-61 - PubMed

[3] Development. 2011 Mar;138(6):1017-31 - PubMed

[4] Development. 2011 Mar;138(6):1017-31 - PubMed

[5] Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4515-20 - PubMed

[6] Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4515-20 - PubMed

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[9] J Leukoc Biol. 1989 Jul;46(1):1-10 - PubMed

[10] J Leukoc Biol. 1989 Jul;46(1):1-10 - PubMed

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A view of human haematopoietic development from the Petri dish

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A view of human haematopoietic development from the Petri dish

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