Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma

Inflammation. 2017 Apr;40(2):697-707. doi: 10.1007/s10753-016-0480-6.


Asthma is a chronic airway inflammation that is characterized by intense eosinophil infiltrates, mucus hypersecretion, airway remodeling, and airway hyperresponsiveness. Interleukin (IL)-35 and IL-37 are two cytokines with anti-inflammatory effects found in immune response. Recent findings suggested that expressions of IL-35 and IL-37 are abnormal in asthma. Functional analysis further confirmed the important roles of them in the pathogenesis of asthma. The present study reviewed the updated evidence indicating the roles of IL-35 and IL-37 in asthma. Hopefully, the information obtained may lead to a better understanding of the pathogenesis of the disease.

Keywords: IL-35; IL-37; asthma.

Publication types

  • Review

MeSH terms

  • Animals
  • Asthma / etiology
  • Asthma / immunology*
  • Asthma / pathology
  • Humans
  • Inflammation
  • Inflammation Mediators / immunology
  • Inflammation Mediators / physiology*
  • Interleukin-1 / immunology
  • Interleukin-1 / physiology*
  • Interleukins / immunology
  • Interleukins / physiology*


  • IL37 protein, human
  • Inflammation Mediators
  • Interleukin-1
  • Interleukins
  • interleukin-35, human