Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms

T G Razina; E P Zueva; A V Ulrich; O Yu Rybalkina; A V Chaikovskii; N V Isaikina; G I Kalinkina; V V Zhdanov; G N Zyuz'kov

doi:10.1007/s10517-016-3554-4

Antitumor Effects of Sorbus aucuparia L. Extract Highly Saturated with Anthocyans and Their Mechanisms

Bull Exp Biol Med. 2016 Nov;162(1):93-97. doi: 10.1007/s10517-016-3554-4. Epub 2016 Nov 23.

Authors

T G Razina¹, E P Zueva², A V Ulrich², O Yu Rybalkina^{2

3}, A V Chaikovskii², N V Isaikina⁴, G I Kalinkina⁴, V V Zhdanov², G N Zyuz'kov^{2

3}

Affiliations

¹ E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia. razinatg22@gmail.com.
² E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
³ National Research Tomsk State University, Tomsk, Russia.
⁴ Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.

PMID: 27878717
DOI: 10.1007/s10517-016-3554-4

Abstract

The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.

Keywords: B-16 melanoma; Fructus Sorbi aucupariae; Lewis lung carcinoma; anthocyans; tumor stem cells.

MeSH terms

Animals
Anthocyanins / pharmacology*
Antineoplastic Agents, Alkylating / pharmacology*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Carcinoma, Lewis Lung / drug therapy*
Carcinoma, Lewis Lung / pathology
Cyclophosphamide / pharmacology*
Drug Synergism
Drug Therapy, Combination
Female
Fruit / chemistry
Injections, Intramuscular
Lymphatic Metastasis
Melanoma, Experimental / drug therapy*
Melanoma, Experimental / pathology
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Neoplastic Stem Cells / drug effects
Neoplastic Stem Cells / pathology
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
Sorbus / chemistry
Tumor Burden / drug effects
Tumor Cells, Cultured

Substances

Anthocyanins
Antineoplastic Agents, Alkylating
Antineoplastic Agents, Phytogenic
Plant Extracts
Cyclophosphamide