Natural Variation of Molecular and Morphological Gibberellin Responses

Plant Physiol. 2017 Jan;173(1):703-714. doi: 10.1104/pp.16.01626. Epub 2016 Nov 22.


Although phytohormones such as gibberellins are essential for many conserved aspects of plant physiology and development, plants vary greatly in their responses to these regulatory compounds. Here, we use genetic perturbation of endogenous gibberellin levels to probe the extent of intraspecific variation in gibberellin responses in natural accessions of Arabidopsis (Arabidopsis thaliana). We find that these accessions vary greatly in their ability to buffer the effects of overexpression of GA20ox1, encoding a rate-limiting enzyme for gibberellin biosynthesis, with substantial differences in bioactive gibberellin concentrations as well as transcriptomes and growth trajectories. These findings demonstrate a surprising level of flexibility in the wiring of regulatory networks underlying hormone metabolism and signaling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / genetics
  • Arabidopsis / metabolism*
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism*
  • Gene Expression Regulation, Plant
  • Genetic Variation
  • Gibberellins / metabolism*
  • Mixed Function Oxygenases / genetics
  • Mixed Function Oxygenases / metabolism*
  • Plant Growth Regulators / metabolism
  • Plant Leaves / genetics
  • Plant Leaves / growth & development
  • Plants, Genetically Modified


  • Arabidopsis Proteins
  • Gibberellins
  • Plant Growth Regulators
  • Mixed Function Oxygenases
  • gibberellin 20 oxidase 1, Arabidopsis