Curcumin and Boswellia serrata Modulate the Glyco-Oxidative Status and Lipo-Oxidation in Master Athletes

Nutrients. 2016 Nov 21;8(11):745. doi: 10.3390/nu8110745.


Background: Chronic intensive exercise is associated with a greater induction of oxidative stress and with an excess of endogenous advanced glycation end-products (AGEs). Curcumin can reduce the accumulation of AGEs in vitro and in animal models. We examined whether supplementation with curcumin and Boswellia serrata (BSE) gum resin for 3 months could affect plasma levels of markers of oxidative stress, inflammation, and glycation in healthy master cyclists.

Methods: Forty-seven healthy male athletes were randomly assigned to Group 1, consisting of 22 subjects given a Mediterranean diet (MD) alone (MD group), and Group 2 consisted of 25 subjects given a MD plus curcumin and BSE (curcumin/BSE group). Interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), high-sensitivity c-reactive protein (hs-CRP), total AGE, soluble receptor for AGE (sRAGE), malondialdehyde (MDA), plasma phospholipid fatty acid (PPFA) composition, and non-esterified fatty acids (NEFA) were tested at baseline and after 12 weeks.

Results: sRAGE, NEFA, and MDA decreased significantly in both groups, while only the curcumin/BSE group showed a significant decline in total AGE. Only the changes in total AGE and MDA differed significantly between the curcumin/BSE and MD groups.

Conclusions: Our data suggest a positive effect of supplementation with curcumin and BSE on glycoxidation and lipid peroxidation in chronically exercising master athletes.

Keywords: advanced glycation end-products; curcumin; exercise; inflammation; oxidative stress.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Antioxidants / administration & dosage*
  • Athletes*
  • Bicycling
  • Boswellia / chemistry*
  • Curcumin / administration & dosage*
  • Diet, Mediterranean
  • Dietary Supplements*
  • Glycation End Products, Advanced / metabolism*
  • Humans
  • Inflammation Mediators / blood
  • Italy
  • Lipid Peroxidation / drug effects*
  • Lipids / blood*
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Oxidative Stress / drug effects*
  • Physical Endurance
  • Phytotherapy
  • Pilot Projects
  • Plant Extracts / administration & dosage*
  • Plant Extracts / isolation & purification
  • Plants, Medicinal
  • Time Factors


  • Antioxidants
  • Glycation End Products, Advanced
  • Inflammation Mediators
  • Lipids
  • Plant Extracts
  • Curcumin