Demystifying HDL Cholesterol-A "Human Knockout" to the Rescue?

Clin Chem. 2017 Jan;63(1):33-36. doi: 10.1373/clinchem.2016.258244. Epub 2016 Oct 6.

Authors

Amit V Khera¹, Paul M Ridker²

Affiliations

¹ Center for Human Genetic Research and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
² Center for Cardiovascular Disease Prevention and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. pridker@partners.org.

PMID: 27881451
DOI: 10.1373/clinchem.2016.258244

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cardiovascular Diseases / drug therapy
Cholesterol, HDL / metabolism*
Humans
Hypolipidemic Agents / therapeutic use
Lipoproteins, HDL / metabolism*
Mice
Mutation
PCSK9 Inhibitors
Proprotein Convertase 9 / genetics*
Serine Proteinase Inhibitors / therapeutic use

Substances

Cholesterol, HDL
Hypolipidemic Agents
Lipoproteins, HDL
PCSK9 Inhibitors
Serine Proteinase Inhibitors
PCSK9 protein, human
Proprotein Convertase 9