MediterrAsian Diet Products That Could Raise HDL-Cholesterol: A Systematic Review

Biomed Res Int. 2016:2016:2025687. doi: 10.1155/2016/2025687. Epub 2016 Nov 1.


Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjects. Methods. A systematic review has been done involving all the English written studies published from the 1st of January 1958 to the 31st of March 2016. Results. The results of this systematic review indicate that the dietary supplementation with red yeast rice, bergamot, artichoke, and virgin olive oil has promising effects on the increase of HDL-C serum levels. The artichoke leaf extract and virgin olive oil appear to be particularly interesting, while bergamot extract needs further research and the effect of red yeast rice seems to be limited to patients with previous myocardial infarction. Conclusions. Various MediterrAsian diet products or natural extracts may represent a potential intervention treatment to raise HDL-C in dyslipidemic subjects.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Biological Products
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / diet therapy
  • Cardiovascular Diseases / prevention & control*
  • Cholesterol, HDL / blood*
  • Cynara scolymus
  • Diet, Mediterranean*
  • Humans
  • Olive Oil
  • Plant Oils


  • Biological Products
  • Cholesterol, HDL
  • Olive Oil
  • Plant Oils
  • red yeast rice
  • bergamot oil