α-Ketoglutarate dehydrogenase complex moonlighting: ROS signalling added to the list: An Editorial highlight for 'Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?'

Emilio Fernandez; Juan P Bolaños

doi:10.1111/jnc.13862

α-Ketoglutarate dehydrogenase complex moonlighting: ROS signalling added to the list: An Editorial highlight for 'Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?'

J Neurochem. 2016 Dec;139(5):689-690. doi: 10.1111/jnc.13862.

Authors

Emilio Fernandez^{1

2}, Juan P Bolaños^{1

2}

Affiliations

¹ Department of Biochemistry and Molecular Biology, University of Salamanca, Salamanca, Spain.
² Institute of Functional Biology and Genomics (IBFG), CSIC-University of Salamanca, Salamanca, Spain.

Abstract

Read the highlighted article 'Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?' on page 823.

Publication types

Editorial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Ketoglutarate Dehydrogenase Complex / antagonists & inhibitors
Ketoglutarate Dehydrogenase Complex / metabolism*
Mitochondria / enzymology*
Neurodegenerative Diseases / enzymology*
Neurodegenerative Diseases / therapy
Reactive Oxygen Species / metabolism*

Substances

Reactive Oxygen Species
Ketoglutarate Dehydrogenase Complex

Grants and funding

R21 DA037678/DA/NIDA NIH HHS/United States