Effect of prostaglandin F3 alpha on gastric mucosal injury by ethanol in rats: comparison with prostaglandin F2 alpha

Prostaglandins. 1989 Apr;37(4):493-504. doi: 10.1016/0090-6980(89)90098-1.

Abstract

In humans eicosapentaenoic acid can be converted to 3-series prostaglandins (PGF3 alpha, PGI3, and PGE3). Whether 3-series prostaglandins can protect the gastric mucosa from injury as effectively as their 2-series analogs is unknown. Therefore, we compared the protective effects of PGF3 alpha and PGF2 alpha against gross and microscopic gastric mucosal injury in rats. Animals received a subcutaneous injection of either PGF3 alpha or PGF2 alpha in doses ranging from 0 (vehicle) to 16.8 mumol/kg and 30 min later they received intragastric administration of 1 ml of absolute ethanol. Whether mucosal injury was assessed 60 min or 5 min after ethanol, PGF3 alpha was significantly less protective against ethanol-induced damage than PGF2 alpha. These findings indicate that the presence of a third double bond in the prostaglandin F molecule between carbons 17 and 18 markedly reduces the protective effects of this prostaglandin on the gastric mucosa.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alprostadil* / analogs & derivatives*
  • Animals
  • Dinoprost / pharmacology*
  • Dose-Response Relationship, Drug
  • Ethanol / toxicity*
  • Female
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / pathology*
  • Gastrointestinal Hemorrhage / chemically induced
  • Gastrointestinal Hemorrhage / prevention & control
  • Prostaglandins E / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Stomach Diseases / chemically induced
  • Stomach Diseases / prevention & control

Substances

  • Prostaglandins E
  • Ethanol
  • prostaglandin E3
  • Dinoprost
  • Alprostadil