WONOEP appraisal: Imaging biomarkers in epilepsy

Epilepsia. 2017 Mar;58(3):315-330. doi: 10.1111/epi.13621. Epub 2016 Nov 24.

Abstract

Neuroimaging offers a wide range of opportunities to obtain information about neuronal activity, brain inflammation, blood-brain barrier alterations, and various molecular alterations during epileptogenesis or for the prediction of pharmacoresponsiveness as well as postoperative outcome. Imaging biomarkers were examined during the XIII Workshop on Neurobiology of Epilepsy (XIII WONOEP) organized in 2015 by the Neurobiology Commission of the International League Against Epilepsy (ILAE). Here we present an extended summary of the discussed issues and provide an overview of the current state of knowledge regarding the biomarker potential of different neuroimaging approaches for epilepsy.

Keywords: Biomarker; Blood-brain barrier; Epileptogenesis; Imaging; Inflammation; Traumatic brain injury.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers* / metabolism
  • Blood-Brain Barrier / physiopathology
  • Education
  • Epilepsy* / diagnosis
  • Epilepsy* / metabolism
  • Epilepsy* / therapy
  • Humans
  • Neurobiology
  • Neuroimaging*

Substances

  • Biomarkers