Recent applications of metabolomics to advance microbial biofuel production

Curr Opin Biotechnol. 2017 Feb:43:118-126. doi: 10.1016/j.copbio.2016.11.006. Epub 2016 Nov 22.


Biofuel production from plant biomass is a promising source of renewable energy [1]. However, efficient biofuel production involves the complex task of engineering high-performance microorganisms, which requires detailed knowledge of metabolic function and regulation. This review highlights the potential of mass-spectrometry-based metabolomic analysis to guide rational engineering of biofuel-producing microbes. We discuss recent studies that apply knowledge gained from metabolomic analyses to increase the productivity of engineered pathways, characterize the metabolism of emerging biofuel producers, generate novel bioproducts, enable utilization of lignocellulosic feedstock, and improve the stress tolerance of biofuel producers.

Publication types

  • Review

MeSH terms

  • Bacteria / metabolism*
  • Biofuels / microbiology*
  • Biomass*
  • Industrial Microbiology*
  • Metabolic Engineering*
  • Metabolomics / methods*


  • Biofuels