Interleukin-1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin

Biochem Biophys Res Commun. 1989 Aug 15;162(3):1578-84. doi: 10.1016/0006-291x(89)90855-3.


To examine the hypothesis that interleukin-1 may inhibit the secretion of gastric acid, the present study was carried out using pylorusligated rats. Based upon three lines of evidence, we report here that interleukin-1, both endogenously released and exogenously administered, suppresses gastric acid secretion and that the interleukin-1-induced inhibition of acid output is possibly mediated by prostaglandin. First, lipopolysaccharide, a potent stimulant of the release and production of endogenous interleukin-1, caused the suppression of gastric acid, and this response was dose-related. Second, the intraperitoneal injection of interleukin-1 resulted in a dose-related inhibition of gastric acid output. Third, the administration of indomethacin completely blocked the suppression of gastric acid secretion induced by interleukin-1. These results demonstrated for the first time that IL-1 might be involved in the regulation of gastric secretion.

MeSH terms

  • Animals
  • Corticotropin-Releasing Hormone / physiology
  • Dose-Response Relationship, Drug
  • Gastric Juice / metabolism*
  • Gastric Mucosa / metabolism
  • Indomethacin / pharmacology
  • Interleukin-1 / pharmacology*
  • Lipopolysaccharides / pharmacology
  • Male
  • Prostaglandins / physiology
  • Rats
  • Rats, Inbred Strains
  • Secretory Rate / drug effects


  • Interleukin-1
  • Lipopolysaccharides
  • Prostaglandins
  • Corticotropin-Releasing Hormone
  • Indomethacin