Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
, 23 (3), 153-156

Giant Leiomyoma Arising From the Mediastinal Pleura: A Case Report

Case Reports

Giant Leiomyoma Arising From the Mediastinal Pleura: A Case Report

Naoki Haratake et al. Ann Thorac Cardiovasc Surg.


This report presents a rare case involving a patient with a giant leiomyoma originating from the mediastinal pleura. The patient underwent a medical examination, and chest radiography revealed a giant tumor. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a well demarcated, heterogeneous mass which seemed to originate from the posterior mediastinum. Positron emission tomography (PET) showed the uptake of this tumor with a standardized uptake value of 4.9. We suspected that this tumor was a solitary fibrous tumor, and the patient underwent a surgical resection. Intraoperative exploration revealed a well-encapsulated tumor measuring 15 × 11 cm that appeared to originate from the mediastinal pleura. Immunohistochemical findings revealed a benign leiomyoma. We finally diagnosed the patient with a mediastinal leiomyoma. The present report describes CT, MRI, and PET findings of leiomyoma, and presents a review of relevant literature.

Keywords: computed tomography; leiomyoma; magnetic resonance imaging; mediastinal pleura; positron emission tomography.


Fig. 1
Fig. 1. (A) Chest X-ray showed a huge mass in the left lower field. (B) Chest computed tomography showed a well demarcated and heterogeneous mass measuring 12 × 9 cm, originating from the posterior mediastinum or pleura and adjacent to the left lower lobe and descending aorta.
Fig. 2
Fig. 2. (A) Macroscopic findings of resected tumor: the tumor was well encapsulated by fibrous tissue, and the borderline was sharp. (B) Intrathoracic findings: the stalk of the tumor seemed to originate from the mediastinal pleura. (C) Histological findings of the tumor (hematoxylin and eosin staining): mature smooth muscle cells proliferated in an interlacing, fascicular, or irregular pattern associated with focal liquefaction and fibrosis. (D) Immunohistochemical findings of the tumor: the tumor cells were positive for alpha-smooth muscle actin.

Similar articles

See all similar articles

Cited by 1 PubMed Central articles

  • Intercostal Leiomyoma in a Child: Review of the Literature
    K Anastasiadis et al. Pan Afr Med J 28, 283. PMID 29942415. - Review
    Leiomyomas of the chest wall are very rare. In a review of the current literature twelve cases were found, of which only one concerns of an intercostal leiomyoma of the c …

Publication types

MeSH terms