The disparate origins of ovarian cancers: pathogenesis and prevention strategies

Nat Rev Cancer. 2017 Jan;17(1):65-74. doi: 10.1038/nrc.2016.113. Epub 2016 Nov 25.


Ovarian cancer is the fifth cause of cancer-related death in women and comprises a histologically and genetically broad range of tumours, including those of epithelial, sex cord-stromal and germ cell origin. Recent evidence indicates that high-grade serous ovarian carcinoma, clear cell carcinoma and endometrioid carcinoma primarily arise from tissues that are not normally present in the ovary. These histogenetic pathways are informing risk-reduction strategies for the prevention of ovarian and ovary-associated cancers and have highlighted the importance of the seemingly unique ovarian microenvironment.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Ovarian Neoplasms* / etiology
  • Ovarian Neoplasms* / pathology
  • Ovarian Neoplasms* / physiopathology
  • Ovarian Neoplasms* / prevention & control
  • Tumor Microenvironment / physiology