A consensus statement on the gender perspective in lung cancer

Clin Transl Oncol. 2017 May;19(5):527-535. doi: 10.1007/s12094-016-1578-x. Epub 2016 Nov 24.


Lung cancer is the most common cancer globally and has the highest mortality. Although this disease is not associated with a particular gender, its incidence is rising among women, who are diagnosed at an increasingly younger age compared with men. One of the main reasons for this rise is women taking up smoking. However, many non-smoking women also develop this disease. Other risk factors implicated in the differential development of lung cancer in women are genetic predisposition, tumour histology and molecular profile. Proportionally more women than men with lung cancer have a mutation in the EGFR gene. This consensus statement reviews the available evidence about the epidemiological, biological, diagnostic, therapeutic, social and psychological aspects of lung cancer in women.

Keywords: EGFR; Gender; Lung cancer; Quality of life; Smoking.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Lung Neoplasms / epidemiology*
  • Lung Neoplasms / etiology
  • Male
  • Risk Factors
  • Sex Factors*