Evaluation of the Effects of Cucumis sativus Seed Extract on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial

J Food Sci. 2017 Jan;82(1):214-218. doi: 10.1111/1750-3841.13569. Epub 2016 Nov 25.


Hyperlipidemia is associated with increased risk of atherosclerosis; therefore, control of this risk factor is very important in preventing atherosclerosis. Cucumber (Cucumis sativus) seed is used traditionally as a lipid-lowering nutritional supplement. The aim of this study was to evaluate the effect of cucumber seed extract on serum lipid profile in adult patients with mild hyperlipidemia. In a randomized double-blind placebo-controlled clinical trial, hyperlipidemic patients with inclusion criteria were randomly and equally assigned to either Cucumis or placebo groups and used one medicinal or placebo capsule, respectively, once daily with food for 6 wk. Body mass index (BMI) as well as fasting serum levels of total cholesterol, triglycerides (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) were measured for all patients pre- and post-intervention and finally the changes were compared between the groups. Twenty-four patients in Cucumis group and 23 patients in placebo group completed the study. Cucumis seed extract resulted in significant reduction of total cholesterol (P = 0.016), LDL-C (P < 0.001), TG (P < 0.001), and BMI (P < 0.001) as well as significant increase of HDL-C (P = 0.012) compared to placebo. In conclusion, the consumption of C. sativus seed extract with daily dose of 500 mg results in desirable effects on serum lipid profile in adult hyperlipidemic patients. Therefore, cucumber seed could be considered as a food supplement for treatment of dyslipidemia.

Keywords: Cucumis sativus seed; body mass index; clinical trial; hyperlipidemia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Atherosclerosis / blood
  • Atherosclerosis / prevention & control
  • Cholesterol / blood
  • Cholesterol, LDL / blood
  • Cucumis sativus*
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Hyperlipidemias / blood
  • Hyperlipidemias / drug therapy*
  • Hypolipidemic Agents / pharmacology
  • Hypolipidemic Agents / therapeutic use*
  • Lipids / blood*
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Male
  • Middle Aged
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Seeds
  • Triglycerides / blood


  • Cholesterol, LDL
  • Hypolipidemic Agents
  • Lipids
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Plant Extracts
  • Triglycerides
  • Cholesterol