Coagulation and sepsis

Thromb Res. 2017 Jan;149:38-44. doi: 10.1016/j.thromres.2016.11.007. Epub 2016 Nov 19.

Abstract

Severe sepsis is almost invariably associated with systemic activation of coagulation. There is ample evidence that demonstrates a wide-ranging cross-talk between hemostasis and inflammation, which is probably implicated in the pathogenesis of organ dysfunction in patients with sepsis. Inflammation not only leads to initiation and propagation of coagulation activity, but coagulation also markedly influences inflammation. Molecular mechanisms that play a role in inflammation-induced effects on coagulation have been recognized in much detail. Pro-inflammatory cells and cyto- and chemokines can activate the coagulation system and downregulate crucial physiological anticoagulant mechanisms. Initiation of coagulation activation and consequent thrombin generation is caused by expression of tissue factor on activated monocytes and endothelial cells and is ineffectually offset by tissue factor pathway inhibitor. At the same time, endothelial-associated anticoagulant pathways, in particular the protein C system, is impaired by pro-inflammatory cytokines. Also, fibrin removal is severely obstructed by inactivation of the endogenous fibrinolytic system, mainly as a result of upregulation of its principal inhibitor, plasminogen activator inhibitor type 1 (PAI-1). Increased fibrin generation and impaired break down lead to deposition of (micro)vascular clots, which may contribute to tissue ischemia and ensuing organ dysfunction. The foundation of the management of coagulation in sepsis is the explicit and thorough treatment of the underlying disorder by antibiotic treatment and source control measures. Adjunctive strategies focused at the impairment of coagulation, including anticoagulants and restoration of physiological anticoagulant mechanisms, may supposedly be indicated and have been found advantageous in experimental and initial clinical trials.

Keywords: Coagulation; Coagulation inhibitors; Disseminated intravascular coagulation; Inflammation; Sepsis.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Coagulation*
  • Chemokines / blood
  • Disseminated Intravascular Coagulation / blood*
  • Disseminated Intravascular Coagulation / complications*
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / therapy
  • Humans
  • Inflammation / blood
  • Inflammation / complications
  • Plasminogen Activator Inhibitor 1 / blood
  • Sepsis / blood*
  • Sepsis / complications*

Substances

  • Chemokines
  • Plasminogen Activator Inhibitor 1