Pathogenesis of COPD and Asthma

Clive Page; Blaze O'Shaughnessy; Peter Barnes

doi:10.1007/164_2016_61

Pathogenesis of COPD and Asthma

Handb Exp Pharmacol. 2017:237:1-21. doi: 10.1007/164_2016_61.

Authors

Clive Page¹, Blaze O'Shaughnessy², Peter Barnes³

Affiliations

¹ Sackler Institute of Pulmonary Pharmacology, King's College London, 150 Stamford Street, London, SE1 9NH, UK. clive.page@kcl.ac.uk.
² Sackler Institute of Pulmonary Pharmacology, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
³ Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3 6LY, UK.

PMID: 27888348
DOI: 10.1007/164_2016_61

Abstract

Asthma and COPD remain two diseases of the respiratory tract with unmet medical needs. This review considers the current state of play with respect to what is known about the underlying pathogenesis of these two chronic inflammatory diseases of the lung. The review highlights why they are different conditions requiring different approaches to treatment and provides a backdrop for the subsequent chapters in this volume discussing recent advances in the pharmacology and treatment of asthma and COPD.

Keywords: Asthma; Bronchial hyperresponsiveness; COPD; Pathogenesis.

Publication types

Review

MeSH terms

Aging
Airway Remodeling
Asthma / etiology*
Bronchial Hyperreactivity / etiology
Humans
Oxidative Stress
Pulmonary Disease, Chronic Obstructive / etiology*