Update on Burkitt Lymphoma

Hematol Oncol Clin North Am. 2016 Dec;30(6):1333-1343. doi: 10.1016/j.hoc.2016.07.009.


Because of its rarity and high curability, progress in advancing therapeutics in Burkitt lymphoma (BL) has been difficult. Over recent years, several new mutations that cooperate with MYC have been identified, and this has paved the way for testing novel agents in the disease. One of the challenges of most standard approaches typically used is severe treatment-related toxicity that often leads to discontinuation of therapy. To that point, there has been recent success developing intermediate intensity approaches that are well tolerated in all patient groups and maintain high cure rates in a multicenter setting.

Keywords: Burkitt lymphoma; CCND3; Endemic; ID3; MYC; Risk-adapted; Sporadic; TCF3.

Publication types

  • Review

MeSH terms

  • Burkitt Lymphoma* / genetics
  • Burkitt Lymphoma* / metabolism
  • Burkitt Lymphoma* / therapy
  • Humans
  • Mutation*
  • Proto-Oncogene Proteins c-myc* / genetics
  • Proto-Oncogene Proteins c-myc* / metabolism


  • MYC protein, human
  • Proto-Oncogene Proteins c-myc