Uncommon Anal Neoplasms

Surg Oncol Clin N Am. 2017 Jan;26(1):143-161. doi: 10.1016/j.soc.2016.07.009.


Uncommon neoplasms of the anal canal are associated with significant diagnostic dilemma in clinical practice and a high index of suspicion and pathologic expertise is needed. The incidence is likely to increase, particularly of small, incidental lesions found because of use of more frequent colonoscopy and high-definition MRI. Generally treatment follows that of the same histologic subtype in other anatomic location. Surgical intervention is the cornerstone for cure in early/localized disease; however, removal of the anal canal is associated with significant morbidities and quality of life issues. A centralized global registry/database established under the auspices of the International Rare Care Initiative collaboration would be useful.

Keywords: Anal lymphoma; Anal melanoma; Anal neuroendocrine tumor; Unusual cancers.

Publication types

  • Review

MeSH terms

  • Anus Neoplasms / pathology*
  • Humans
  • Incidence
  • Lymphoma / pathology*
  • Melanoma / pathology*
  • Neuroendocrine Tumors / pathology*
  • Quality of Life